abstract：BACKGROUND:Previous studies have identified numerous biological, psychological and social characteristics of persons with psychogenic non-epileptic seizures (PNES) however the strength of many of these factors have not been evaluated to determine which are predictive of the diagnosis compared to those that may only be ...

journal_title：Epilepsy research

authors： Elliott JO,Charyton C

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:This study aimed to test the hypothesis that high-dose prednisolone (4 mg/kg/day) may be more efficacious than usual-dose (2 mg/kg/day) prednisolone for spasm resolution at 14-days in children with infantile spasms. METHODS:This was a randomized, open-label-trial conducted at a tertiary-level-hospital from ...

journal_title：Epilepsy research

authors： Chellamuthu P,Sharma S,Jain P,Kaushik JS,Seth A,Aneja S

更新日期：2014-10-01 00:00:00

abstract：AIM:This cross-sectional study examined whether growth parameters were associated with epilepsy in children living in a rural community in sub-Saharan Africa (SSA). MATERIALS AND METHODS:A cross-sectional study was performed in the Hai District Demographic Surveillance Site (HDSS), Tanzania in which 6-14 year old chil...

journal_title：Epilepsy research

authors： Rogathe JJ,Todd J,Hunter E,Walker R,Ngugi A,Newton C,Burton K

更新日期：2014-10-01 00:00:00

abstract：AIM:To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ). BACKGROUND:Individuals with epilepsy have increased risk factors for vascular disease, particu...

journal_title：Epilepsy research

authors： Keenan N,Sadlier LG,Wiltshire E

更新日期：2014-08-01 00:00:00

abstract：:It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia...

journal_title：Epilepsy research

authors： Moseley BD,Britton JW

更新日期：2014-07-01 00:00:00

abstract：:We evaluated the outcomes of intracranial electroencephalography (iEEG) recording and subsequent resective surgery in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE). Thirty-two patients were identified from the Mayo Clinic Epilepsy Surgery Database (Arizona, Florida, and Minnesota...

journal_title：Epilepsy research

authors： Lee RW,Hoogs MM,Burkholder DB,Trenerry MR,Drazkowski JF,Shih JJ,Doll KE,Tatum WO 4th,Cascino GD,Marsh WR,Wirrell EC,Worrell GA,So EL

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of stiripentol as add-on therapy in Japanese patients with Dravet syndrome treated with clobazam (CLB) and valproate (VPA). METHODS:In this open-label study, patients aged 1-30 years entered a 4-week baseline phase, followed by a 4-week stiripentol dose-adjustment and 12-wee...

journal_title：Epilepsy research

authors： Inoue Y,Ohtsuka Y,STP-1 Study Group.

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:To identify clinical risk factors for Dravet syndrome (DS) in a population of children with status epilepticus (SE). MATERIAL AND METHODS:Children aged between 1 month and 16 years with at least one episode of SE were referred from 6 pediatric neurology centers in Switzerland. SE was defined as a clinical seiz...

journal_title：Epilepsy research

authors： Le Gal F,Lebon S,Ramelli GP,Datta AN,Mercati D,Maier O,Combescure C,Rodriguez MI,Seeck M,Roulet E,Korff CM

更新日期：2014-05-01 00:00:00

abstract：:Periventricular nodular heterotopia (PVNH) is a neuronal migrational disorder often associated with pharmacoresistant epilepsy (PRE). Resective surgery for PVNH is limited by its deep location, and the overlying eloquent cortex or white matter. Stereotactic MR guided laser interstitial thermal therapy (MRgLITT) has re...

journal_title：Epilepsy research

authors： Esquenazi Y,Kalamangalam GP,Slater JD,Knowlton RC,Friedman E,Morris SA,Shetty A,Gowda A,Tandon N

更新日期：2014-03-01 00:00:00

abstract：:There are many difficulties involved with the treatment of epilepsy, and these problems have driven the search for new agents to control epileptic seizures. Calcitonin is a peptide hormone that has been well studied and shown to have a positive effect on neuropathic and chronic pain. The mechanism by which calcitonin ...

journal_title：Epilepsy research

authors： Aksoy D,Solmaz V,Erbas O

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Diffusion tensor tractography of the anterior extent of the optic radiation - Meyer's loop - prior to temporal lobe resection (TLR) may reduce the risk for postoperative visual field defect. Currently there is no standardized way to perform tractography. OBJECTIVE:To visualize Meyer's loop using determinist...

journal_title：Epilepsy research

authors： Lilja Y,Ljungberg M,Starck G,Malmgren K,Rydenhag B,Nilsson DT

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:The present study was planned as there is paucity of outcome data of children with infantile spasms, from India where profile of patients is different from the western world. Moreover, most previous studies have either not used strict inclusion criteria or standardized psychometric tests for developmental outco...

journal_title：Epilepsy research

authors： Sehgal R,Gulati S,Sapra S,Tripathi M,Kabra M,Pandey RM

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:The present study aims to determine the initialization and propagation of typical absence seizures using magnetoencephalography (MEG). METHOD:Fourteen drug-naïve children with childhood absence epilepsy (CAE) were studied using a 275-Channel MEG system. The spectral signatures of epileptic activity were assess...

journal_title：Epilepsy research

authors： Miao A,Tang L,Xiang J,Guan Q,Ge H,Liu H,Wu T,Chen Q,Yang L,Lu X,Hu Z,Wang X

更新日期：2014-03-01 00:00:00

abstract：:Mutations in GABRG2, which encodes the γ2 subunit of GABAA receptors, can cause both genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. Most GABRG2 truncating mutations associated with Dravet syndrome result in premature termination codons (PTCs) and are stably translated into mutant proteins wit...

journal_title：Epilepsy research

authors： Ishii A,Kanaumi T,Sohda M,Misumi Y,Zhang B,Kakinuma N,Haga Y,Watanabe K,Takeda S,Okada M,Ueno S,Kaneko S,Takashima S,Hirose S

更新日期：2014-03-01 00:00:00

abstract：:GABA transporters (GATs) are an essential element of the GABAergic system, which regulate excitability in the central nervous system and are thus used as targets for anticonvulsive therapy. However, in the immature nervous system the functions of the GABAergic system and the expression profile of GATs are distinct fro...

journal_title：Epilepsy research

authors： Sharopov S,Chen R,Sun H,Kolbaev SN,Kirischuk S,Luhmann HJ,Kilb W

更新日期：2014-02-01 00:00:00

abstract：:Comorbid conditions may affect the quality of life in persons with epilepsy (PWE) more than seizures. Using legally mandated healthcare encounter data, somatic, psychiatric, and neurodevelopmental comorbidities in a large population-based cohort of PWE, were compared to persons with migraine (PWM), a similar neurologi...

journal_title：Epilepsy research

authors： Selassie AW,Wilson DA,Martz GU,Smith GG,Wagner JL,Wannamaker BB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:To describe the clinical findings in a family with a benign form of mesial temporal lobe epilepsy and to identify the causative genetic factors. METHODS:All participants were personally interviewed and underwent neurologic examination. The affected subjects underwent EEG and most of them neuroradiological exam...

journal_title：Epilepsy research

authors： Fanciulli M,Di Bonaventura C,Egeo G,Fattouch J,Dazzo E,Radovic S,Spadotto A,Giallonardo AT,Nobile C

更新日期：2014-02-01 00:00:00

abstract：:Novel treatments for epilepsy are necessary because many epilepsy patients are resistant to medication. Metabotropic glutamate receptors (mGluRs), specifically mGluR 2 and 3, may serve as antiepileptic drug targets because of their role in controlling synaptic release. In this study, we administered a Group 2 mGluR ag...

journal_title：Epilepsy research

authors： Caulder EH,Riegle MA,Godwin DW

更新日期：2014-02-01 00:00:00

abstract：:Changes in EEG synchronization, i.e., spatio-temporal correlation, with amygdala-hippocampal stimulation were studied in patients with temporal lobe epilepsy. Synchronization was evaluated for high frequency, 130 Hz, pseudo-monophasic or biphasic charge-balanced pulses. Desynchronization was most frequently induced by...

journal_title：Epilepsy research

authors： Tyrand R,Seeck M,Pollo C,Boëx C

更新日期：2014-02-01 00:00:00

abstract：:Chemical kindling, as an experimental model of epileptogenesis, is induced by repetitive administration of subconvulsive amount of excitatory drugs. Kindled mice do not typically display spontaneous recurrent seizures, but are instead characterized by enhanced seizure susceptibility to convulsive stimulations. In orde...

journal_title：Epilepsy research

authors： Zhang YF,Li SL,Xiong TQ,Yang LB,Li YN,Tan BH,Liu Q,Li YC

更新日期：2014-01-01 00:00:00

abstract：:Focal epilepsy (FE) is one of the most common forms of adult epilepsy and is usually regarded as a multifactorial disorder. Febrile seizures (FS) often appear during childhood in a subtype of FE patients, i.e. with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). FS are the most common human convulsive eve...

journal_title：Epilepsy research

authors： Belhedi N,Perroud N,Karege F,Vessaz M,Malafosse A,Salzmann A

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Rolandic epilepsy (RE) is an idiopathic focal childhood epilepsy with a well-established neuropsychological profile of language impairment. The aim of this study is to provide a functional correlate that links rolandic (sensorimotor) pathology to language problems using functional MRI. MATERIALS AND METHO...

journal_title：Epilepsy research

authors： Besseling RM,Overvliet GM,Jansen JF,van der Kruijs SJ,Vles JS,Ebus SC,Hofman PA,de Louw AJ,Aldenkamp AP,Backes WH

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Since intracranial electrode implantation has limited spatial sampling and carries significant risk, placement has to be effective and efficient. Structural and functional imaging of several different modalities contributes to localising the seizure onset zone (SoZ) and eloquent cortex. There is a need to su...

journal_title：Epilepsy research

authors： Rodionov R,Vollmar C,Nowell M,Miserocchi A,Wehner T,Micallef C,Zombori G,Ourselin S,Diehl B,McEvoy AW,Duncan JS

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Cryptogenic focal epilepsy (CFE) is a heterogeneous clinical disorder including patients with severe refractory forms and patients with a fairly good prognosis. Predictors of prognosis in CFE are poorly understood. The aim of this retrospective study is to identify long-term (5-year) prognostic predictors in pa...

journal_title：Epilepsy research

authors： Gasparini S,Ferlazzo E,Beghi E,Tripepi G,Labate A,Mumoli L,Leonardi CG,Cianci V,Latella MA,Gambardella A,Aguglia U

更新日期：2013-11-01 00:00:00

abstract：:Treatment of epileptic patients with valproic acid (VPA) may be associated with substantial weight changes that may increase morbidity and impair adherence to the treatment regimen. VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resis...

journal_title：Epilepsy research

authors： Belcastro V,D'Egidio C,Striano P,Verrotti A

更新日期：2013-11-01 00:00:00

abstract：STUDY OBJECTIVE:Non-convulsive seizures/status epilepticus occur in approximately 20% of comatose, non-cardiac arrest intensive care unit (ICU) patients, and are associated with increased mortality. The prevalence and clinical significance of seizures in comatose survivors of cardiac arrest undergoing therapeutic hypot...

journal_title：Epilepsy research

authors： Knight WA,Hart KW,Adeoye OM,Bonomo JB,Keegan SP,Ficker DM,Szaflarski JP,Privitera MD,Lindsell CJ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Asymmetry of hippocampal internal architecture (HIA) clarity has been suggested to be a sign of hippocampal sclerosis (HS) and is frequently associated with other MRI findings of HS. The goal of this work is to use a previously developed HIA visual scoring system (Ver Hoef et al., 2013) to quantify HIA asymm...

journal_title：Epilepsy research

authors： Ver Hoef LW,Williams FB,Kennedy RE,Szaflarski JP,Knowlton RC

更新日期：2013-09-01 00:00:00

abstract：:Classification of seizures arising from the cortical motor system classically distinguishes between primary motor seizures and supplementary motor area (SMA) seizures. With the aim of better characterizing the underlying networks of motor seizures, we quantitatively studied the "epileptogenicity" of brain structures i...

journal_title：Epilepsy research

authors： Bonini F,McGonigal A,Wendling F,Régis J,Scavarda D,Carron R,Chauvel P,Bartolomei F

更新日期：2013-09-01 00:00:00

abstract：:The ideal proof-of-principle study design provides a strong efficacy signal over the shortest duration, while exposing the fewest patients possible. Data from a large database (Pfizer Inc) which studied add-on pregabalin for the treatment of partial seizures was used to model how duration of baseline, post-randomizati...

journal_title：Epilepsy research

authors： French JA,Cabrera J,Emir B,Whalen E,Lu F

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To determine the minimum enrollment duration for identifying incident cases of epilepsy in administrative data. METHODS:We performed a retrospective dynamic cohort study using Ohio Medicaid data from 1992 to 2006 to identify a total of 5037 incident epilepsy cases who had at least 1 year of follow-up prior to ...

journal_title：Epilepsy research

authors： Bakaki PM,Koroukian SM,Jackson LW,Albert JM,Kaiboriboon K

更新日期：2013-09-01 00:00:00

abstract：:It has been suggested that loss of the astrocytic water channel aquaporin-4 (AQP4) from perivascular endfeet in sclerotic hippocampi contributes to increased seizure propensity in human mesial temporal lobe epilepsy (MTLE). Whether this loss occurs prior to or as a consequence of epilepsy development remains to be res...

journal_title：Epilepsy research

authors： Alvestad S,Hammer J,Hoddevik EH,Skare Ø,Sonnewald U,Amiry-Moghaddam M,Ottersen OP

更新日期：2013-07-01 00:00:00

abstract：:We describe the clinical and radiological features of a family with a homozygous mutation in TBC1D24. The phenotype comprised onset of focal seizures at 2 months with prominent eye-blinking, facial and limb jerking with an oral sensory aura. These were controllable with medication but persisted into adult life. Associ...

journal_title：Epilepsy research

authors： Afawi Z,Mandelstam S,Korczyn AD,Kivity S,Walid S,Shalata A,Oliver KL,Corbett M,Gecz J,Berkovic SF,Jackson GD

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To retrospectively analyze the electroclinical features, etiology, treatment and prognosis of 117 patients with encephalopathy with status epilepticus during sleep (ESES) or continuous spike and waves slow sleep (CSWSS) syndrome with a long-term follow-up. METHODS:Charts of 117 patients with ESES/CSWSS syndrom...

journal_title：Epilepsy research

authors： Caraballo RH,Veggiotti P,Kaltenmeier MC,Piazza E,Gamboni B,Lopez Avaria MF,Noli D,Adi J,Cersosimo R

更新日期：2013-07-01 00:00:00

abstract：:Glutamic acid decarboxylase autoantibodies (GADA) and anti-cardiolipin autoantibodies (ACA) have been detected in adult subjects with epilepsy, though the functional implications of these findings are a matter of debate. This study aimed to determine the prevalence of GADA and ACA and to investigate their clinical sig...

journal_title：Epilepsy research

authors： Veri K,Uibo O,Talvik T,Talvik I,Metsküla K,Napa A,Vaher U,Õiglane-Šlik E,Rein R,Kolk A,Traat A,Uibo R

更新日期：2013-07-01 00:00:00

abstract：:Assessing the functional reserve of key memory structures in the medial temporal lobes (MTL) of pre-surgical patients with intractable temporal lobe epilepsy (TLE) remains a challenge. Conventional functional MRI (fMRI) memory paradigms have yet to fully convince of their ability to confidently assess the risk of a po...

journal_title：Epilepsy research

authors： Bonnici HM,Sidhu M,Chadwick MJ,Duncan JS,Maguire EA

更新日期：2013-07-01 00:00:00

abstract：:Early Onset Absence Epilepsy constitutes an Idiopathic Generalized Epilepsy with absences starting before the age of four years. Mutations in SLC2A1, encoding the glucose transporter, account for approximately 10% of EOAE cases. The role of SLC2A1 mutations in absence epilepsies with a later onset has not been assesse...

journal_title：Epilepsy research

authors： Muhle H,Helbig I,Frøslev TG,Suls A,von Spiczak S,Klitten LL,Dahl HA,Brusgaard K,Neubauer B,De Jonghe P,Tommerup N,Stephani U,Hjalgrim H,Møller RS

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined ...

journal_title：Epilepsy research

authors： Ohmori I,Hayashi K,Wang H,Ouchida M,Fujita N,Inoue T,Michiue H,Nishiki T,Matsui H

更新日期：2013-07-01 00:00:00

abstract：:To assess whether epileptic children have abnormal values of some trace elements, the aim of this preliminary study was to assess the serum zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr) concentrations in 23 children with initial recognition of epilepsy before beginning of pharmacological therapy in comparison w...

journal_title：Epilepsy research

authors： Wojciak RW,Mojs E,Stanislawska-Kubiak M,Samborski W

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Antiepileptic drugs (AEDs) may have adverse effects on bone metabolism and bone mineral density (BMD). The aim of this study is to determine the changes of bone metabolism and BMD in epilepsy patients who are undergoing levetiracetam (LEV) monotherapy. METHODS:Drug-naïve, sixty-one patients with recent onset e...

journal_title：Epilepsy research

authors： Koo DL,Joo EY,Kim D,Hong SB

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a multisystem genetic disorder affecting multiple organs, including the brain, and very often associated with epileptic activity. Language acquisition and development seems to be altered in a significant proportion of patients with TSC. In the present study, we used magn...

journal_title：Epilepsy research

authors： Gallagher A,Tanaka N,Suzuki N,Liu H,Thiele EA,Stufflebeam SM

更新日期：2013-03-01 00:00:00